The CD61 antigen (platelet glycoprotein GPIIIa) is the 110 kDa integrin β3 subunit, con-covalently associated with the integrin αIIb chain (CD41, platelet GPIIb) to form the GPIIb-IIIa complex (αIIb-β3 integrin). Independently of CD41, CD61 is also associated with the integrin αV (CD51) to form the vitronectin receptor. CD41/CD61 is expressed only by platelets and megakaryocytes, whereas CD51/CD61 is found on osteoclasts, endothelial cells, macrophages, fibroblasts, smooth muscle, synovial lining cells and renal glomeruli.

Specifications

Specificity CD61
Form FITC
Clone SZ21
Flow Product Line IOTest
Clone Description The SZ21 antibody is specific for the PlA1, not the PlA2 form of GPIIIa. It inhibits platelet aggregation and secretion induced by collagen, arachidonic acid, and thrombin. This antibody also inhibits fibrinogen binding to human platelets induced by ADP, arachidonic acid and PAF.
Isotype IgG1 Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Other Names b3 integrin, beta3 integrin, CD61, Glycoprotein IIIa, gpIIIa, Integrin beta3-chain
UNSPSC 41116015

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IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.