The CD244 antigen, also called 2B4, is a 38 kDa cell surface signal transduction molecule found on almost all human NK cells. It induces a granule independent killing mechanism by NK effector cells. It is also found on γδ TCR T cells and appoximately half of peripheral αβ TCR CD8+ T cells. It is not found on B or naïve CD8+ T cells. Upon activation, most CD8+ T cells become CD244-positive. However, a small but significant minority of CD8+ T cells remain CD244-negative. This subset is associated with lower cytotoxic activity, lower γ-IFN production and higher IL-4 and IL-10 production. CD244 is a high affinity receptor for CD48.

Specifications

Specificity CD244
Form PE
Clone C1.7
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Other Names 2B4, C1.7, CD244, p38
UNSPSC 41116015

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.