Also called TCRBV11S1 Vβ11 is the human variable β11 chain of the T cell receptor. Two Vβ11 sequences are described, PL3.12 and PH15. These sequences differ only in their leader sequence and therefore lead to the same mature protein. An invariant Vα24/Vβ11 T cell receptor is expressed in all individuals by clonal expanded CD4– CD8– T cells, reactive to bacterial antigens. This unique lymphocyte population restricted by the CD1d molecule recognition has been identified as the natural killer T (NKT) cells. Vβ11 is expressed by 0.4% to 0.9% of peripheral CD3+ cells in normal blood. This sequence is also referred to as TRBV25-1 (based on the IMGT gene nomenclature).

Specifications

Specificity TCR Vβ11
Form FITC
Clone C21
Flow Product Line IOTest
Clone Description The C21 recognizes the gene product of  PL3.12 and PH15 sequences. The specificity of this antibody has been confirmed at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995.
Isotype IgG2a Mouse
Format Liquid
Size 1 mL
Regulatory Status ASR
Target Species Human
Other Names TCR VBeta 11, TCRBV11S1
UNSPSC 41116015

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