CD58 is a glycoprotein of 65-70 kDa, either transmembrane or glycosylphosphatidylinositol (GPI)-anchored. CD58 was first described as the lymphocyte-function associated antigen 3 (LFA-3). LFA-3 was further shown to interact with CD2 suggesting an important role in various immunological responses via T-cell adhesion and activation. CD58 mediates adhesion between killer and target cells, antigen presenting cells and T cells. This antigen is widely expressed on leucocytes, erythrocytes and endothelial cells.

Specifications

Specificity CD58
Form PE
Clone AICD58
Flow Product Line IOTest
Clone Description The AICD58 antibody is a blocking antibody in LFA-3 mediated adhesion. This antibody was used as a CD58 reference mAb during HLDA 6.
Isotype IgG2a Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Other Names CD58, LFA-3, lymphocyte function associated antigen-3
UNSPSC 41116015

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