CD49d is the integrin α4 chain that non-covalently pairs with CD29 (β1 chain) to form the very late activation antigen 4 (VLA-4), or with the integrin β7 chain. CD49d is a transmembrane glycoprotein of 145 kDa devoid of disulfide bond. Complexed to β1 or β7 integrins, CD49d is not only involved in cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1), but also in intercellular leucocyte interactions. It is expressed by monocytes, lymphocytes, eosinophils, thymocytes and Langerhans cells.

Specifications

Target Species Human
Specificity CD49d
Other Names CD49d, Integrin alpha 4 chain, Integrin α4-chain, VLA-4, VLA-alpha4-chain
Fluorochrome Unlabeled
Regulatory Status ASR
Size 0.2 mg / 0.2 mg
Format Freeze-dried
Clone HP2/1
Isotype IgG1 Mouse
Clone Description The HP2/1 antibody blocks the interaction of VLA-4 with VCAM-1. HP2/1 was used as a CD49d reference monoclonal antibody during the HLDA 6.
Cross Reactivity HP2/1 cross reacts with: Indian Rhesus. HP2/1 cross reacts with: Bovine, Ovine, Caprine, Equine, Canine, Feline, Mink, Llama, Rabbit, Carp

Technical Documents

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ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.