The CD54 antigen, previously known as ICAM-1 (InterCellular Adhesion Molecule-1), is a 90 kDa transmembrane glycoprotein. With seven potential N-linked glycosylation sites, its structure, as that of CD50 (ICAM-3) and CD102 (ICAM-2), is related to the Immunoglobulin family. The CD54 antigen mediates the adhesion of T lymphocytes with Antigen-Presenting Cells (APC) and is involved in T cell to T cell and T cell to B cell interactions. It is also involved in the adhesion of monocytes, lymphocytes and neutrophils to activated endothelium. It binds to the integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). It is a receptor for the rhinovirus. It is expressed by endothelial cells and by many other cell types upon activation.

Specifications

Target Species Human
Specificity CD54
Other Names CD54, ICAM-1, intercellular adhesion molecule 1
Fluorochrome FITC
Regulatory Status ASR
Size 2 mL
Format Liquid
Flow Product Line IOTest
Clone 84H10
Isotype IgG1 Mouse
Clone Description 84H10 antibody inhibits ICAM-1 mediated adhesion to LFA-1.
Cross Reactivity 84H10 cross reacts with: Canine

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