The CD49b antigen is a transmembrane glycoprotein of 150 kDa also known as the α-2 integrin and as platelet GPIa. CD49b non-covalently pairs with the β-1 integrin (CD29, GPIIa) to form the VLA-2 (very late activation antigen) complex. CD49b complexed to CD29 is involved in cell adhesion to collagen. It is expressed by platelets, activated T lymphocytes and thymocytes.

Specifications

Specificity CD49b
Form Unlabeled
Clone Gi9
Clone Description The Gi9 antibody reacts with the molecule carrying the Br(a) as well as the Br(b) alloantigen. This antibody inhibits the adhesion of platelets to collagen. It detects human alloantibodies (anti-Br a,b) against VLA-2 by MAIPA assay. Gi9 was used as a CD49b reference monoclonal antibody during the HLDA 6. Gi9 reacts with platelets and weakly with monocytes. It also stains most adherent cell lines and T lymphocytes in culture.
Isotype IgG1 Mouse
Format Freeze-dried
Size 0.2 mg / 0.2 mg
Regulatory Status RUO
Target Species Human
Other Names CD49b, gpIa, Integrin alpha 2 chain, Integrin alpha2-chain, platelet gpla, VLA-2, VLA-alpha 2-chain
UNSPSC 41116015

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.