The CD7 antigen is a membrane-embedded glycoprotein with a molecular weight of 40 kDa. It is expressed at an early stage of T lineage ontogeny, during the extrathymic prothymocytic formation. CD7 expression persists throughout T lymphocytes differentiation defining CD7 as a pan-T marker. It is also expressed on thymocytes, on the majority of resting T lymphocytes, and Natural Killer cells (NK), and on a subset of pre-B lymphocytes and B lymphocytes from foetal bone marrow. CD7 expression is also detected on pluripotent hematopoietic stem cells. Mature B-lymphocytes, cells from erythroid, myeloid and megacaryocytic lineage do not express the CD7 molecule. The CD7 molecule is involved in T lymphocytes activation. Its expression may be quantitatively up-regulated on stimulated T lymphocytes.

Specifications

Specificity CD7
Form FITC
Clone 8H8.1
Flow Product Line IOTest
Isotype IgG2a Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Cross Reactivity 8H8.1 cross reacts with: Equine
Other Names CD7, gp40, T cell leukemia antigen
UNSPSC 41116015

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