The CD37 antigen is a 40-52 kDa single chain transmembrane protein with 4 transmembrane domains (Tetraspan/TM4SF). This molecule has both its NH2- and COOH-termini inside the cells, and is heavily glycosylated on one extracellular loop. The main feature of this antigen is its high content of hydrophobic residues (45%). The CD37 antigen is strongly expressed on the surface of human peripheral blood B lymphocytes and on B lymphocytes from germinal centers. In the ontogeny of B cells, this antigen appears late, after the pre-B stage, and is not expressed on plasma cells. The CD37 antigen has a low expression on T lymphocytes, granulocytes, and monocytes. A weak reactivity is observed with other cellular types such as Langerhans cells, macrophages, normal medullar granulous cells and peripheral blood polymorphonuclear cells. CD37 is involved in signal transduction.

Specifications

Specificity CD37
Form FITC
Clone BL14
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Other Names CD37, gp40-52
UNSPSC 41116015

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