CD11c (integrin αX subunit, also known as leucocyte surface antigen p150, Axb2 and CR4) is a member of the integrin family. Like other leucocyte integrins (CD11a, CD11b, CD11d), CD11c is non-covalently associated with the β2 integrin subunit (CD18). CD11c is a transmembrane glycoprotein of 145-150 kDa, mainly expressed by monocytes, macrophages and NK cells, and to a lesser extent by granulocytes, dendritic cells and some subsets of T and B cells. CD11c / CD18 has an important role in cytotoxic T cell killing, in the adhesion of monocytes and neutrophils to the endothelium and induces cellular activation. The CD11c is ∼87% homologous in sequence to CD11b, and recognizes similar ligands including complement factor fragment iC3b, fibrinogen, CD54 and bacterial lipopolysaccharide.

Specifications

Specificity CD11c
Form PC7
Clone BU15
Flow Product Line IOTest
Clone Description The BU15 antibody was used as a CD11c reference mAb (ref.6) during HLDA 6.
Isotype IgG1 Mouse
Format Liquid
Size 100 Tests
Regulatory Status CE
Target Species Human
Cross Reactivity BU15 cross reacts with: Canine
Other Names p150,95, alphaX integrin chain, CR4, axb2
UNSPSC 41116015

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