CD137, also known as 4-1BB or ILA (for Induced by Lymphocyte Activation) is a 39kDa type I integral membrane protein of the TNF/NGF family. CD137 is expressed on activated T and B cells, NK cells, monocytes and follicular dendritic cells. Differential splicing leads to the release of a 16-kDa soluble from activated T cells. CD137 is involved in monocyte activation by inducing an increase in the production of IL-6, IL-8 and TNF-α, and an inhibition of IL-10 production. In addition, CD137 plays a role in the induction of B lymphocyte apoptosis and the co-stimulation of T-cell proliferation.

Specifications

Specificity CD137
Form ECD
Clone 4B4-1
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Other Names 4-1BB, CD137, ILA
UNSPSC 41116015

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