CD73 is a 5’-nucleotidase anchored to the membrane by a glycosylphosphatidylinositol (GPI) structure. CD73 is a dimer of two identical 70 kD subunits. A soluble form of CD73 can be shed from the membrane through proteolytic cleavage or hydrolysis of the GPI anchor by phosphatidylinositol-specific phospholipase. CD73 is expressed on subsets of T and B cells, follicular dendritic cells and on epithelial and endothelial cells. CD73 possesses the enzymatic activity of a 5’-nucleotidase and catalyzes the dephosphorylation of purine and pyrimidine ribo- and deoxyribonucleoside mono-phosphates to theirs corresponding nucleosides. An alternate function for CD73 is to regulate the availability of adenosine by converting AMP to adenosine. There is evidence that the expression and function of this enzyme are upregulated under hypoxic conditions, as well as by the presence of several pro-inflammatory mediators, such as transforming growth factor (TGF)-β interferons (IFNs), tumor necrosis factor (TNF)-α , interleukin (IL)-1 β and prostaglandin E2. CD73 can transmit activation signals to T cells and mediates adhesion of lymphocytes to follicular dendritic cells and endothelial cells. The CD73/adenosine pathway is a potent additional suppressive pathway of Treg cells and also confers a suppressive anti-inflammatory function on the uncommitted primed precursor Thpp cell type.

Specifications

Specificity CD73
Form PE
Clone AD-2
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 1 mL
Regulatory Status ASR
Target Species Human
Other Names CD73, Ecto-5'-nucleotidase
UNSPSC 41116015

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