CD183, also called CXCR3, is a 41kDa transmembrane G protein-coupled CXC receptor, belonging to the family of chemokine receptors. It has selectivity for IP10, Mig and I-TAC chemokines. Cellular production of CD183 ligands is induced by interferon, suggesting an important role of CD183 in Th1-type inflammatory processes. CD183 signaling induces chemotactic migration in inflammation-associated effector T cells, involving integrin activation and cytoskeletal changes. CD183 is expressed on T cells (Th1), NK cells, dendritic cells, mast cells, eosinophils. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Specifications

Target Species Human
Specificity CD183
Other Names CD183, CKR-L2, CXCR3, GPR9, IP10-R, Mig-R
Fluorochrome Alexa Fluor* 488
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line IOTest
Clone G025H7
Isotype IgG1 Mouse

Technical Documents

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.