Perforin is a 70 kD N-glycosylated modified cytolytic protein. Following synthesis and post-translational modifications, perforin monomers are packaged into lysosome-like cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Both types of cells kill their cellular targets by mechanisms that require direct contact between the effector and target cells. Cytoplasmic granule toxins, predominantly perforin, and a family of structurally related serine proteases (granzymes) with various substrate specificities are secreted by exocytosis and together induce apoptosis of the target cell. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.

Specifications

Specificity Perforin
Form Pacific Blue*
Clone dG9
Flow Product Line IOTest
Isotype IgG2b Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Other Names Perforin
UNSPSC 41116015

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IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.