CD141, also known as thrombomodulin (TM) and BDCA-3, is an endothelial cell surface receptor. It is a 75 kD type I membrane glycoprotein and members of C-type lectin family. Two major isoforms exist, differentiated by the presence or not of sulfated glycosaminoglycan at Ser/Thr region. CD141 antigen is expressed on neutrophils, monocytes, platelets, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. It is a cofactor in the activation of protein C and initiation of the protein C anticoagulant pathway by binding to its ligand thrombin.

Specifications

Specificity CD141
Form FITC
Clone M80
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 1 mL
Regulatory Status ASR
Target Species Human
Other Names BDCA-3, CD141, Thrombomodulin
UNSPSC 41116015

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IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.