The anti-IgM antibody binds to circulating IgM as well as to IgM antibodies bound to the FcμR. The FcμR is a transmembrane single sialoglycoprotein of 60 kD with O-linked oligosaccharides. It contains an extracellular Ig-like domain homologous to two other IgM-binding receptors (polymeric Ig receptor and Fcα/μR) but exhibits an exclusive Fcμ-binding specificity. Unlike other FcRs, the major cell types expressing FcμR are adaptive immune cells, including B and T lymphocytes. The FcμR can be expressed as a cell surface activation antigen throughout the pre-B and B cell stages in differentiation. Receptor expression is not directly linked with IgM production, as both μ- pre-B cells and isotype-switched B cells may express the FcμR. The FcμR is thus the third member of a family of Fc receptors expressed on B-lineage cells, and its preferential expression on activated B cells suggests a potential role in the response to antigens.

Specifications

Specificity IgM
Form APC
Clone SA-DA4
Flow Product Line IOTest
Clone Description The SA-DA4 monoclonal antibody binds specifically to mu heavy chain of Human Immunoglobulin (IgM).
Isotype IgG1 Mouse
Format Liquid
Size 50 Tests
Regulatory Status RUO
Target Species Human
UNSPSC 41116015

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.