The CD161 antigen is also designated as the NKR-P1A molecule. CD161 is a type II integral membrane protein expressed as a monomer of 44 kDa or as a disulphide-linked homodimer of 80 kDa. The carboxy-terminal extracellular domain is homologous to Ca++-dependent (C-type) lectin superfamily. CD161 is an activatory NK receptor, but in contrast with other NK receptors such as KIR (p58, p70, p140) and CD94/NKG2, CD161-mediated activation is not HLA-dependent. CD161 is expressed on all NK cells and on sub-populations of T lymphocytes.

Specifications

Specificity CD161
Form PC7
Clone 191B8
Flow Product Line IOTest
Clone Description The 191B8 antibody partially blocks the spontaneous NK cytotoxicity in the P815 model.
Isotype IgG2a Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Other Names CD161, killer cell lectin-like receptor subfamily B, member 1, NKR-P1, NKR-P1A
UNSPSC 41116015

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