Signal transducers and activators of transcription (STATs) is a group of transcription factors. They play a critical role in diverse signal transduction pathways that govern cellular survival, proliferation, differentiation and apoptosis. They mediate signaling from a number of membrane receptors that include interferon, interleukin (IL-2), hematopoietic and growth factors receptors (GM-CSF, growth hormone and prolactin). Stat5 signals can be detected in GM-CSF stimulated monocytes as opposed to non activated control samples. Phosphorylation at Tyr694 is obligatory for Stat5 activation. STAT protein activation may be mediated by members of both JAK and Src family members following cytokine/growth factor stimulation. JAK kinases appear to be essential for the phosphorylation of the cytokine receptors which results in the creation of docking sites on the receptors for binding of SH2- containing proteins such as STATs, Src-kinases and other signaling intermediates. The integration of these diverse signaling cues from active JAK kinases, members of the Src-family kinases and STAT proteins, leads to cell proliferation, cell survival and differentiation, the end-point of the cytokine/growth factor stimulus. STAT protein activation has been observed in diverse cell types. Constitutive STAT activation has been detected in a wide variety of human primary tumor specimens and tumor cell lines. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility.

Specifications

Form PE
Clone C71E5
Isotype IgG1 Rabbit
Format Liquid
Size 25 Tests
Regulatory Status RUO
Target Species Human
UNSPSC 41116015

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The listed regulatory status for products correspond to one of the below:
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ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.