S6 ribosomal protein is a component of the 40S ribosomal subunit. It is involved in mRNA translation upregulation. S6 ribosomal protein activation may be mediated by members of PI3K-PKB/Akt/mTORCI signaling pathways. The first component of this pathway consists of surface receptors for growth factors such as mitogens, growth factors, and cytokines. These receptors undergo tyrosine phosphorylation in their intracellular domains following binding with their respectives ligands. Activated Protein Kinases (MAPK). MAPK cascades are key siignaling pathways involved in the regulation of normal cell proliferation, survival and differentiation. Phosphorylation of the S6 MAPK. Phosphorylation of S6 ribosomal protein correlates with an increase in mRNA transcripts translation containing an oligopyrimidine tract in their 5' untranslated regions. These 5'Top mRNA transripts encode proteins involved in cell cycle progression as well as ribosomal proteins and elongation factors necessary for translation. Phosphorylation sites in S6 ribosomal protein include the Ser235, Ser236, Ser40 and Ser244 residues.

Specifications

Form Pacific Blue*
Clone D57.2.2E
Isotype IgG Rabbit
Format Liquid
Size 25 Tests
Regulatory Status RUO
Target Species Human
UNSPSC 41116015

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.