The CD158f molecule (also known as KIR2DL5) is a 60 kDa monomeric glycoprotein with two Ig-like extracellular domains and a long cytoplasmic domain. CD158f is an inhibitory receptor and a member of the KIR (Killer-cell Immunoglobulin-like Receptor) family of receptors, which recognizes subsets of HLA-Class I alleles. KIR2DL5 gene is found in only a fraction of individuals in the population, and it is represented in the human genome by two genes, KIR2DL5A and KIR2DL5B. KIR2DL5 has alleles with mRNA transcripts that are clonally distributed in NK and T lymphocytes. KIR2DL5 is predicted to encode a purely inhibitory receptor, according to its signaling motifs (two ITIMs (Immunoreceptor Tyrosine-based Inhibition Motif) and a 1 transmembrane region lacking charged amino acid residues). KIR2DL5, together with KIR2DL4, are the only members of a gene lineage coding for KIR with a D0–D2 organization of the Ig-like domains, which distinguishes them from all other KIR2Ds, having domains of the D1-D2 type. Upon tyrosine phosphorylation, KIR2DL5 recruits the Src homology region 2-containing proteintyrosine phosphatase-2 and, to a lesser extent, Src homology region 2-containing protein tyrosinephosphatase-1. KIR2DL5 is an inhibitory receptor which may play a specialized role in innate immunity. In particular, it is expressed in a fraction of blood NK cells with the CD56dim phenotype and in a variable proportion of circulating T lymphocytes.

Specifications

Specificity CD158f
Form APC
Clone UP-R1
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Other Names CD158f, KIR2DL5
UNSPSC 41116015

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.