Human T cells recognize foreign antigens, in the context of host HLA molecules through the T-cell receptor for antigen (TcR). The TcRs are molecular complexes which comprise two units: a recognition unit, composed of either α-β or γ-δ heterodimer, which are present on the cell surface in a mutually exclusive manner, and, a transducing unit, the CD3 complex, common to α-β and γ-δ heterodimers, which triggers the T cell when the recognition unit is occupied by the antigen. The recognition units recognize any possible foreign antigen and the diversity necessary for this function of recognition is generated by somatic recombination the TcR genes. There are four TcR gene loci (α, β, γ and δ). Each of them is composed of several V (for variable) segments, coding for about 90 amino acids, very short D (for diversity) segments (α and δ loci only), and short J (for joining) segments (about 15 amino acids), and one or two C (for constant) segments.

Specifications

Specificity TCR PAN α/β
Form APC
Clone IP26A
Flow Product Line IOTest
Clone Description The IP26A antibody recognizes a monomorphic determinant of the human α/B chain of the TcR complex.
Isotype IgG1 Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
UNSPSC 41116015

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.