The CD42b antigen (GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with the CD42c (GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on platelets and megakaryocytes. It has also been reported on vascular and tonsillar endothelial cells. The CD42a-d complex is the receptor for von Willebrand's factor and is known as von Willebrand's factor-dependent adhesion receptor.

Specifications

Target Species Human
Specificity CD42b
Other Names CD42b, glycoprotein GPIb-a, gpIb, GPIb-a, platelet glycoprotein GPIb-a
Fluorochrome APC
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line IOTest
Clone SZ2
Isotype IgG1 Mouse
Clone Description The SZ2 monoclonal antibody prevents the ristocetin-dependent binding of von Willebrand's factor to platelets and inhibits ristocetin-induced platelet agglutination. Platelet aggregation induced by type I collagen and Platelet Activating Factor (PAF) is also inhibited. The SZ2 antibody immunoprecipitates the components of the GPIb complex. It may also be used in Western Blot.

Technical Documents

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.