CD49d is the integrin α4 chain that non-covalently pairs with CD29 (β1 chain) to form the very late activation antigen 4 (VLA-4), or with the integrin β7 chain. CD49d is a transmembrane glycoprotein of 145 kDa devoid of disulfide bond. Complexed to β1 or β7 integrins, CD49d is not only involved in cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1), but also in intercellular leucocyte interactions. It is expressed by monocytes, lymphocytes, eosinophils, thymocytes and Langerhans cells.

Specifications

Specificity CD49d
Form APC
Clone HP2/1
Flow Product Line IOTest
Clone Description The HP2/1 antibody blocks the interaction of VLA-4 with VCAM-1. HP2/1 was used as a CD49d reference monoclonal antibody during the HLDA 6.
Isotype IgG1 Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Cross Reactivity HP2/1 cross reacts with: Indian Rhesus. HP2/1 cross reacts with: Bovine, Ovine, Caprine, Equine, Canine, Feline, Mink, Llama, Rabbit, Carp
Other Names CD49d, Integrin alpha 4 chain, Integrin α4-chain, VLA-4, VLA-alpha4-chain
UNSPSC 41116015

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