FcγRII proteins exist as six potential isoforms encoded by three genes, designated as A, B, and C. The reported molecular weight of these isoforms are variable between 37 and 43 kDa. All isoforms are similar but not identical in their extracellular regions. The cytoplasmic portion of FcγRIIA and FcγRIIC contains an activatory ITAM motif whereas FcγRIIB contains an inhibitory ITIM motif. Differential splicing of FcγRIIB gene yields to 2 isoforms FcγRIIBb1 and FcγRIIBb2. Monocytes carry all forms of FcγRII, neutrophils carry FcγRIIA and C. FcγRIIB is expressed by B lymphocytes and mast cells.

Specifications

Specificity CD32
Form Krome Orange
Clone 2E1
Flow Product Line IOTest
Clone Description The 2E1 antibody recognizes the antigen isoforms expressed on basophils, neutrophils, eosinophils, platelets and B cells.
Isotype IgG2a Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Cross Reactivity 2E1 cross reacts with: Cynomolgus Monkey, Indian Rhesus, Olive Baboon. 2E1 cross reacts with: Bovine, Ovine, Equine, Mink
Other Names CD32, Fcgamma receptor type II, FcγRII, gp40
UNSPSC 41116015

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