The CD279 antigen, also known as Programmed Death 1 (PD-1), belongs to the immunoglobulin superfamily. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic tail. It is encoded by the PDCD1 gene, which is located on the human chromosome 2q37.3. Immune cell function implicates important modulators known as cosignaling receptors. On T cells, the cosignaling receptors belong to either the immunoglobulin (CD28-like) or TNF receptor (TNFR) superfamilies. The CD28 immunoglobulin-superfamily is composed of coinhibitory and costimulatory receptors. Programmed Death-1 (PD-1) is one of the coinhibitory receptors, with notably Cytotoxic T Lymphocyte Antigen 4 (CTLA4) and CD272 (BTLA). The interaction of PD-1 with its ligands, PD-L1 and PD-L2, plays a critical role in regulating T cell activation and tolerance.

Specifications

Specificity CD279
Form PC7
Clone PD1.3
Flow Product Line IOTest
Clone Description The PD1.3 monoclonal antibody recognizes T cells, activated CD4 and CD8 positive cells and activated B cells. This antibody has been assigned to the CD279 cluster of differentiation during the 8th HLDA Workshop on Human Leukocyte Differentiation Antigens, held in Adelaide, Australia, in 2004.
Isotype IgG2b Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Other Names CD279, PD-1
UNSPSC 41116015

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IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.