The CD158i molecule (also known as p50.3) is a monomeric integral membrane glycoprotein of 50 kDa. This protein belongs to the family of NK receptors for MHC class I molecules. There is another comprehensive nomenclature which refers to this molecule as KIR2DS4; this acronym stands for Killer cell Immunoglobulin (Ig)-like Receptor (KIR), with extracellular part containing 2 Ig domains (2D), and a short (S) cytoplasmic tail. CD158i comprises 2 C-type extracellular Ig domains. The intracytoplasmic portion lacks characteristic ITIM motifs (Immunoreceptor Tyrosine-based Inhibition Motif) and displays a charged residue in the trans-membrane portion. CD158i receptor seems involved in NK cell activation, following HLA-Cw3 supertype recognition. Antibody-induced cross-linking of CD158i (p50.3) results in both early activation events and late effector function.

Specifications

Specificity CD158i
Form APC
Clone FES172
Flow Product Line IOTest
Clone Description The FES172 antibody stains NK subsets, but the p50.3 antigen appears to be expressed only by some individuals, and to be co-expressed with p58 KIRs.
Isotype IgG2a Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Other Names CD158i, KIR2DS4, p50.3
UNSPSC 41116015

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