The CD146 molecule, also known as S-Endo, is a single chain transmembrane glycoprotein with a molecular weight of 118 kDa, belonging to the immunoglobulin superfamily (IgS). The extracellular structure consists of five Ig-like domains: two V-type, and three C2-type Ig-like domains. The CD146 antigen is related to cell adhesion molecules of the IgS family and its presence is concentrated at regions of cell-cell contact, confirming its role in adhesion and particularly in maintenance of monolayer integrity. CD146 is constitutively expressed in the endothelium, and is also observed on other cell types such as smooth muscle cells, and intermediate trophoblasts. Among peripheral whole blood leucocytes, CD146 expression is not detected, except on a subset of activated T-lymphocytes.

Specifications

Specificity CD146
Form PC5
Clone TEA 1/34
Flow Product Line IOTest
Clone Description The TEA 1/34 monoclonal antibody was assigned to the CD146 (Code: E077) during the HLDA 6.
Isotype IgG2a Mouse
Format Liquid
Size 1 mL
Regulatory Status ASR
Target Species Human
Other Names CD146, MCAM, Melanoma cell adhesion molecule, Mel-CAM, MUC18, S-Endo
UNSPSC 41116015

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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.