The CD166 antigen, also known as activated leukocyte cell adhesion molecule (ALCAM), is a single chain type 1 transmembrane glycoprotein, containing 10 potential N-linked glycosylation sites, and belonging to the immunoglobulin superfamily (IgSF). It shows a 100 – 105 kDa molecular weight, and is composed of five extracytoplasmic Ig-like domains linked to a 32-amino acid cytoplasmic tail through a short membrane-spanning region. The CD166 antigen is an adhesion molecule that binds to the CD6 molecule, or forms ALCAM-ALCAM homophilic interactions. Studies suggest that CD166 molecules can oligomerize at the site of cell-cell contact via their three C2-type Ig-like proximal domains. The CD166 molecule appears to be a non-lineage restricted molecule, expressed on a variety of cell types, including selected hematopoietic cells, endothelial cells, cortical and medullar thymic epithelial cells, bone marrow mesenchymal stem cells, fibroblasts, and hepatocytes. In peripheral blood, ALCAM is expressed on activated T- and B-cell subsets, on monocytes, on circulating dendritic cells, and weakly on granulocytes. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration. In the thymus, the interaction between the CD6 molecule, as expressed on CD6+ thymocytes, and the CD166 molecule expressed on thymic epithelial cells may play a role in T cell development. Other studies suggest that the CD166 adhesion molecule is involved in embryonic hematopoiesis, as well as in hemangioblast differentiation and capillary tube formation.

Specifications

Specificity CD166
Form PE
Clone 3A6
Flow Product Line IOTest
Clone Description The 3A6 antibody blocks the binding of the CD6 ligand to its CD166 receptor as seen on adhesion experiments of CD6-expressing COS cells to thymic epithelial cells. The 3A6 antibody was clustered to the CD166 during HLDA 6.
Isotype IgG1 Mouse
Format Liquid
Size 2 mL
Regulatory Status ASR
Target Species Human
Other Names activated leukocyte cell adhesion molecule , ALCAM, CD166, CD6 ligand, HCA, KG-CAM, MEMD, SB10 antigen, SC-1
UNSPSC 41116015

NOT ALL PRODUCTS ARE AVAILABLE IN ALL COUNTRIES
PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.