The CD120b molecule, also known as tumor necrosis factor-receptor 2 (TNF-R2) is a 75 kDa, integral membrane glycoprotein and a member of the tumor necrosis factor (TNF) receptor superfamily. Its extra-membraneous portion shows 4 cysteine-rich domains (CRDs), one of which seems to be required for ligand binding. The CD120b molecule is a receptor for TNF-α. Lymphotoxin-α (LTα), also known as TNF-β when secreted as a soluble homotrimer, as well as the membrane-associated LTα2/β1 heterotrimer. Soluble TNF resulting from cleavage of membrane TNF by the TNF-α converting enzyme (TACE) can also bind to the CD120b receptor. From a functional perspective, signaling by TNF receptor family requires clustering of 3 receptors by trimeric ligands and subsequent association of the intracellular tails with transduction factors, like the TNF receptor-associated factors (TRAF). TNF-R2 triggering can lead to NF-κB activation, but does not result in cell death. However, the most effective cell killing occurs when membrane bound TNF crosslinks both CD120a and CD120b receptors. The CD120b molecule (TNF-R2) is restricted to hematopoietic cells. It is expressed on monocytes, neutrophils, NK cells and dendritic cells, as well as on a subset of T cells. Very weak expression can be seen on some B cells, and no expression is reported on basophils.

Specifications

Specificity CD120b
Form PE
Clone 80M2
Flow Product Line IOTest
Isotype IgG1 Mouse
Format Liquid
Size 100 Tests
Regulatory Status RUO
Target Species Human
Other Names CD120b, TNF-R2, TNFRII, TNFRp75, TNFRSF1B, Tumor necrosis factor-receptor type 2
UNSPSC 41116015

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