CD85d (ILT4) is a member of the new immunoglobulin (Ig)-like transcripts (ILT) family of genes located on human chromosome 19q13.4. ILT4 is also known as leucocyte Ig-like receptor (LIR)-2 and monocyte / macrophage Ig-like receptors (MIR)-10. ILT4 is a transmembrane protein recognized by 42D1 monoclonal antibody. The protein has extracellular Ig-SF domains, and ITIM motifs in the cytoplasmic tail that inhibit cellular responses by recruiting phosphatases such SHP-1. ILT4 is confined to the myelomonocytic lineage as it is expressed on monocytes, macrophages, and dendritic cells (DCs). ILT4 binds to HLA-G molecules with a 3- to 4-fold higher affinity than to classical MHC class I molecules. ILT4 may modulate one or several of the antigen presenting functions mediated by DCs, control inflammatory responses mediated by monocytes / macrophages or inhibit their cytotoxicity. The recognition of HLA-G by ILT4 may play a role in materno-fetal tolerance as HLA-G is selectively expressed in the trophoblast. It has been shown that recipient’s CD8+CD28– T suppressor (Ts) cells may induce tolerance by up-regulating ITL3 and ILT4 expressions in donor’s dendritic cells, rendering these antigen-presenting cells (APCs) tolerogenic.

Specifications

Specificity CD85d
Form PE
Clone 42D1
Flow Product Line IOTest
Isotype IgG2a Rat
Format Liquid
Size 100 Tests
Regulatory Status RUO
Target Species Human
Other Names CD85d, ILT4, LIR2, MIR10
UNSPSC 41116015

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