The CD4 antigen is a single-chain transmembrane glycoprotein with a 59 kDa molecular weight. CD4 binds to a non-polymorphic region of MHC Class II molecules and is a co-receptor in MHC Class II restricted antigen-induced activation. CD4 is expressed on the T "helper" lymphocytes. It is present on most thymocytes where it is frequently co-expressed with CD8. CD4 is also expressed on all monocytes, although with a lower density than on T lymphocytes. CD4+ T lymphocytes are active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 is a receptor for the Human Immunodeficiency Virus type I (HIV-1) envelope protein gp120.

Specifications

Specificity CD4
Form PC5
Clone 13B8.2
Flow Product Line IOTest
Clone Description 13B8.2 monoclonal antibody antagonizes HIV effects in vitro. 13B8.2 recognizes an epitope close to the amino-acid residues 88-89 within the CD4 molecule. 13B8.2 and BL4 recognize different epitopes. 13B8.2 and BL4 are not cross-blocking.
Isotype IgG1 Mouse
Format Liquid
Size 100.00|Tests
Target Species Human
Cross Reactivity 13B8.2 cross reacts with: Hamadyras Baboon, Olive Baboon
Other Names CD4, T4 antigen

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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.