The CD28 antigen (Tp44) is a homodimer of disulfide-linked chains, with a molecular weight of 44 kDa each. CD28 antigen is expressed by a majority of CD3+ T lymphocytes. CD4+ T lymphocytes express the CD28 antigen more frequently than do CD8+ T lymphocytes. CD28 antigen is also present on plasma cells and thymocytes. This antigen is involved in the adhesion of T lymphocytes with B lymphocytes, through the B7/BB-1 (CD80) or B70/B7-2 (CD86) glycoproteins and provides a major co-stimulatory signal for T cell activation.

Specifications

Target Species Human
Specificity CD28
Other Names CD28, CD80/CD86 Ligand, Tp44
Fluorochrome ECD
Regulatory Status RUO
Size 100 Tests
Format Liquid
Flow Product Line IOTest
Clone CD28.2
Isotype IgG1 Mouse
Clone Description The CD28.2 monoclonal antibody costimulates T cell proliferation and cytokine production in the presence of T cell activators (╬▒CD3, PMA, SEB). It inhibits proliferation of CD4+ T lymphocytes. It cross-reacts with Rhesus monkey peripheral blood lymphocytes.

Technical Documents

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The listed regulatory status for products correspond to one of the below:
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ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
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RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.