The CD22 antigen (BL-CAM) is a transmembrane glycoprotein of the immunoglobulin superfamily. It may be expressed as two different isoforms: the α form (130 kDa) and the β form (140 kDa). CD22 antigen is a B cell restricted antigen expressed in the cytoplasm of B cell progenitors and on the surface of mature B lymphocytes. CD22 expression is lost after B-cell activation, prior to the plasma cell stage. It is absent from peripheral blood T lymphocytes, granulocytes, monocytes.

Specifications

Target Species Human
Specificity CD22
Other Names Bgp135, BL-CAM, CD22, Siglec2
Fluorochrome RD1
Regulatory Status ASR
Size 0.5 mL
Format Liquid
Flow Product Line cyto-stat
Clone HD239
Isotype IgG2b Mouse
Clone Description The B3 antibody binds to an epitope located within the first Ig-like domain of CD22 antigen. It can be used to detect intracytoplasmic CD22 in flow cytometry after permeabilization.

Technical Documents

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