The CD10 antigen is referred to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is a type II integral membrane protein of 100 kDa, identified as the human membrane-associated neutral endopeptidase (EC3.4.24.11). It is expressed on uncommitted lymphoid precursors. CD10 expression is lost as cells enter the T lineage. In the B lineage, CD10 expression is lost later in ontogeny, as cells acquire surface Ig expression. It is also expressed on activated and proliferating B cells in the germinal center, and on neutrophils as well as on bone marrow stromal cells. It is also expressed on a number of other cells of epithelial origin.

Specifications

Specificity CD10
Form FITC
Clone J5
Flow Product Line cyto-stat
Isotype IgG2a Mouse
Format Liquid
Size 0.5 mL
Regulatory Status ASR
Target Species Human
Cross Reactivity J5 cross reacts with: Bovine, Ovine, Equine, Mink, Guinea Pig
Other Names CALLA, CD10, Common acute lymphoblastic antigen
UNSPSC 41116015

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