The CD8 antigen is a disulfide-linked dimer, which exists either as a CD8α homodimer or as a CD8α/β heterodimer. CD8α is required for surface expression of CD8β. The molecular weight of each monomer of α or β is approximately 32-34 kDa. CD8 binds to a non-polymorphic domain (α3 domain) of MHC Class I molecules. CD8 is expressed on a subset of human peripheral blood T lymphocytes. A subset of NK cells possess the CD8 antigen but show low to medium density of expression. CD8α homodimer is expressed by NK cells and γ/δ+ T cells. CD8 is also present on most thymocytes where it is frequently co-expressed with CD4, and on a subpopulation of bone marrow cells. The CD8 molecule acts with the T Cell Receptor (TCR) as a coreceptor for MHC class I restricted antigen recognition. CD8 is widely used as a marker of cytotoxic T lymphocytes.

Specifications

Specificity CD8
Form RD1
Clone SFCI21Thy2D3
Flow Product Line coulter clone
Clone Description SFCI21Thy2D3 monoclonal antibody recognizes the α chain of the CD8 molecule.
Isotype IgG1 Mouse
Format Liquid
Size 100 Tests
Regulatory Status IVD, CE
Target Species Human
Cross Reactivity SFCI21Thy2D3 cross reacts with: Common Marmoset
Other Names CD8, T8 antigen
UNSPSC 41116015

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No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.