The Lineage-PE Cocktail is comprised of PE-conjugated CD3, CD14, CD19, CD20 and CD56 antibodies. It enables the positive staining of five immune cell populations (T and B Lymphocytes, NK cells, Monocytes/Macrophages) together, without distinction, in the PE channel using flow cytometry. When combined with fluorescent-labeled antibodies, other than PE, the gating on PE negative cells allows the phenotypical identification of Dendritic cells. • The CD20 molecule is expressed on B lineage cells. Its CD20 expression occurs early in pre-B lymphocyte development, persists throughout B lymphocyte ontogeny and is lost upon ultimate plasma cells differentiation. The CD20 molecule is present on all B lymphocytes whatever the hematopoietic tissue where they are found (peripheral blood, lymph nodes, spleen, tonsil, or bone marrow). CD20 is also expressed, but at low density, on a subset of peripheral blood T lymphocytes. • The CD56 molecule, known as NCAM (Neural Cell Adhesion Molecule) antigen, is expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with natural killer (NK) activity. It is also expressed by a minor subpopulation of CD3+ T cells that mediates reduced cytotoxic activity. It is not found on monocytes, granulocytes, erythrocytes or B lymphocytes. • The CD20 molecule is expressed on B lineage cells. Its CD20 expression occurs early in pre-B lymphocyte development, persists throughout B lymphocyte ontogeny and is lost upon ultimate plasma cells differentiation. The CD20 molecule is present on all B lymphocytes whatever the hematopoietic tissue where they are found (peripheral blood, lymph nodes, spleen, tonsil, or bone marrow). CD20 is also expressed, but at low density, on a subset of peripheral blood T lymphocytes. • The CD56 molecule, known as NCAM (Neural Cell Adhesion Molecule) antigen, is expressed on a subpopulation of peripheral blood large granular lymphocytes and on all cells with natural killer (NK) activity. It is also expressed by a minor subpopulation of CD3+ T cells that mediates reduced cytotoxic activity. It is not found on monocytes, granulocytes, erythrocytes or B lymphocytes.

Specifications

Size 100 Tests
Regulatory Status RUO
Target Species Human
UNSPSC 41116015

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PRODUCT AVAILABILITY AND REGULATORY STATUS DEPENDS ON COUNTRY REGISTRATION PER APPLICABLE REGULATIONS

The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.