The CD31 antigen, also called Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1), is a single-chain membrane glycoprotein of 130 kDa molecular weight related to immunoglobulin superfamily. Its expression has been shown on stem cells of the myeloid lineage, on platelets and endothelial junctions. CD31 has been demonstrated to bind in a homophilic manner (CD31 binds CD31 on opposing cells). It also mediates heterophilic interactions, in particular, CD31 is involved in the migration of leucocytes through the endothelial cell wall, via adhesion to αvβ3 integrin and to CD38. In addition, CD31 participates in outside-in signaling in leucocytes likely through phosphorylation of its intracytoplasmic tyrosine residues 663 and 686 and subsequent association with tyrosine phosphatases SHP-1 and SHP-2. Studies suggest a comparable mechanism of action for CD31 in activation and aggregation of platelets.

Specifications

Clone 1F11
Isotype IgG1 Mouse
Format Freeze-dried
Size 0.2 mg / 0.2 mg
Regulatory Status RUO
Target Species Human

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.