Analytical Ultracentrifugation: Gene Therapy Analytics and GMP Environments
June 25, 2020
1:00 PM EST
The inherent challenges associated with viral vector production are well-established in the literature; viral vector production is a highly inconsistent process, yielding a heterogenous range of partial-to-complete particles with non-uniform genome loads. These factors drive the rationale for robust quality control parameters within the workflows associated with viral vector production.
Sedimentation-Velocity Analytical UltraCentrifugation (SV-AUC) has become a cornerstone analytical platform for providing those quality control parameters essential to uniform production of viral particles with the intended genomic payload. The ability of SV-AUC to rapidly interrogate numerous parameters critical in viral vector production lends better visibility and control, which is turn assist in comporting to cGMP and other regulatory compliance considerations.
- Akash Bhattacharya
Senior Application Scientist
Beckman Coulter Life Sciences
- Lake N. Paul, PHD
- Borries Demeler, PHD
Professor of Chemistry and Biochemistry
Canada 150 Research Chair for Biophysics
Director Canadian Center for Hydrodynamics
University of Lethbridge