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The T cell intracellular antigen 1 (TIA-1) is a 17 kDa cytoplasmic granule-associated protein, expressed in cells possessing cytolytic potential. TIA-1 is also designated as GMP-17 (granule membrane protein of 17 kDa). The GMP-17/TIA-1 molecule could be involved in the molecular signaling cascade during Fas (CD95)-mediated apoptosis. In normal peripheral blood lymphocytes, TIA-1 is expressed by 90% of CD16+, 50-60% of CD8+, and less than 10% of CD4+ cells. Although TIA-1 may be detected in unstimulated T lymphocytes, activated T lymphocytes are induced to express disulfide linked polymers of the 17 kDa protein, also recognized by TIA-1. TIA-1 is expressed by all monocytes and granulocytes, by activated CD4+ T-cell clones and activated natural killer cell clones, and by Con A-activated thymocytes. On the contrary, TIA-1 is not expressed by B lymphocytes or B-cell lines.
: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
: CE-marked products. CE-marked products are labeled for in vitro diagnostic use and can be traded throughout the EU.
: Research Use Only Reagents. These reagents are labeled "For Research Use Only. Not for use in diagnostic procedures."
: Laboratory Use Only Reagents. These reagents are labeled "For Laboratory Use Only."
IVD & CE
: In Vitro Diagnostic Products and CE-Marked Products. These reagents comply with the IVD and CE classifications and are distributed worldwide for in vitro diagnostic use.
ASR & RUO
: Analyte Specific Reagents & Research Use Only Reagents. These reagents are labeled ASR for distribution throughout the Americas and RUO throughout the rest of the world. These products comply with the ASR and RUO definitions above.