Flow Product Line:
Flow Product Type:
Human CD Antibodies
The CD274 antigen is known as Programmed Cell Death 1 ligand 1 (PDCD1LG1 or PD-L1) or B7-H1. It is encoded by a gene located on the human chromosome 9p24. Immune cell function implicates important modulators known as cosignaling receptors. On T cells, the cosignaling receptors belong to either the immunoglobulin (CD28-like) or TNF receptor (TNFR) superfamilies. The CD28 immunoglobulin-superfamily is composed of coinhibitory (CD28, ICOS) and costimulatory receptors. Programmed Death-1 (PD-1) is one of the three coinhibitory receptors with Cytotoxic T Lymphocyte Antigen 4 (CTLA4) and CD272. CD274 antigen is one of the two ligands, with PD-1 ligand 2 (PD-L2), for PD-1 and belongs to the B7 family. The PD-1 - PD-L1 interaction plays a critical role in regulating T cell activation and tolerance. In particular, it plays a role during development by inhibiting the TCR-mediated positive selection of thymocytes. It has also been shown to be implicated in the regulation of CD4 positive T cells proliferation. CD274 antigen is expressed on immature dendritic cells (iDC), mature dendritic cells (mDC), IFN-γ-treated monocytes, and follicular dendritic cells. The PD-L1 monoclonal antibody recognizes dendritic cells, T cells and follicular dendritic cells.
: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
: CE-marked products. CE-marked products are labeled for in vitro diagnostic use and can be traded throughout the EU.
: Research Use Only Reagents. These reagents are labeled "For Research Use Only. Not for use in diagnostic procedures."
: Laboratory Use Only Reagents. These reagents are labeled "For Laboratory Use Only."
IVD & CE
: In Vitro Diagnostic Products and CE-Marked Products. These reagents comply with the IVD and CE classifications and are distributed worldwide for in vitro diagnostic use.
ASR & RUO
: Analyte Specific Reagents & Research Use Only Reagents. These reagents are labeled ASR for distribution throughout the Americas and RUO throughout the rest of the world. These products comply with the ASR and RUO definitions above.