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Alisa Jackson, Beckman Coulter, Inc. The customer presented the Project Management team with the need to automate a sample dilution series to enable them to run IC50 experiments using their ELISA protocols for QC testing of their products. The team designed a system configuration appropriate for their process needs. The designed system included a SAMI EX Assay Workstation based on the BiomekŪ FX with a Cytomat* Microplate Hotel (MPH), Cytomat II incubator, DTX 880 Multimode reader and an ELx405 plate washer. Both the Cytomat MPH and the CII incubator were linked to the deck of the FX via a Cytomat ALP with a bar code reader to track plates and samples. A schematic of the Assay Workstation is shown below (Figure A):
This solution met the needs of the customer very nicely. Specifically, the SAMI EX and Biomek software made it very easy for the customer to create automated methods and use the scheduling software tools to optimize all the steps in their complex processes. In addition, the customer was able to track data and run in a regulated environment so that they were 21 CFR part 11 compliant. However, there is still a need for the customer to upload data to a Watson LIMS system. The customer is very happy with the reproducibility provided by the system; they are able to run their processes overnight thereby increasing their overall throughput. The team designed this system to provide a standardized, fully-supported platform. The customer chose to buy based on price and functionality, but the key success factor in this solution was the flexibility of the SAMI EX and Biomek software packages. This system has been replicated at a sister facility. * All trademarks are the property of their respective owners. For Research Use Only; not for use in diagnostic procedures.
Additional Information: For comments or questions about T3 Update, please contact David Daniels, Ph.D., editor.
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