Beckman Coulter’s PARADIGM™ Detection Platform is a unique, modular system that allows quick and easy configuration by the user. The platform features a selection of detection cartridges that can be interchanged in less than five minutes to meet different assay needs, making this the first user-upgradeable and -configurable multimode reader. It is ideal for labs with multiple users and applications. The high-throughput detector addresses a broad range of plate formats from 6 to 1,536 wells. Capable of reading plates on the fly, the PARADIGM provides an impressive combination of speed and performance.
Eight different detection cartridges will be available, based on detection modes including fluorescence intensity, fluorescence polarization, time-resolved fluorescence, dual-label fluorescence (including FRET), monochromator based absorbance and luminescence. The detection cartridges contain application-specific elements, including wavelength-tuned light sources and optics that are optimized for dedicated applications, enabling the highest level of performance. One example would the HTRF detection cartridge, certified by Cisbio International for their portfolio of for HTRF assays.
The PARADIGM system software comes with a portfolio of generic protocol templates for the most common detection measurements to streamline user start-up and operation. Assay protocols for third-party chemistry kits are also included, allowing the user to simply enter the number of plates as well as the number of samples/plate and read the plate. The menu of kit-specific assay protocols will be expanded through ongoing development with reagent partners. An Auto Update software feature will allow the user to preview available assay protocols and install them with a single click. The PARADIGM Detection Platform operates as a standalone instrument or it can be integrated with Beckman Coulter Biomek® liquid handlers and new BioRAPTR low-volume workstation. It is ideal for a wide range of standard and cell-based assays such as GPCR, green fluorescent protein, apoptosis, cytotoxicity, nuclear receptors and kinases.
“Detection modes are difficult and costly to add to other multimode detectors once the systems are installed. This can result in compromised performance and lab downtime,” commented Jim Barry, marketing manager for Beckman Coulter. “Our new detection cartridge system truly redefines modularity, enabling the user to maximize return on the platform investment.” |
