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Implementation of a High Throughput Screening Laboratory at McMaster University

Rebecca Hartlen, Jan Blanchard, Jonathan Cechetto, Michela Juran, John Brennan, Gerry Wright and Eric Brown
Department of Biochemistry, McMaster University, Hamilton, ON Canada L8N 3Z5

McMaster University - http://www.mcmaster.ca

In a project sponsored by the Ontario Research and Development Challenge Fund (ORDCF), a high throughput-screening laboratory has been established at McMaster University. The ORDCF is a Government of Ontario initiative designed to promote excellence in research and development within Ontario Universities and other research institutions through private and public sector partnerships. The McMaster HTS Lab is therefore a joint venture among the ORDCF, the university and the private sector. The lab is associated with the Department of Biochemistry at McMaster and has been designed to be highly flexible in order to meet the needs of multiple users wishing to evaluate a variety of assays. The mandate of the McMaster HTS Lab is to provide excellence and innovation in biomolecular screening, and the lab is primarily used by McMaster scientists searching for novel probes to fuel their biological and biochemical research initiatives. The McMaster HTS Lab is also a unique resource for external scientists in both academia and industry who will have access through collaborative and contract research agreements.

Features

  • A newly renovated laboratory designed specifically for HTS
  • An integrated SAGIAN™ Core system designed to be highly flexible to screen a variety of different assays
  • A compound library of over 60,000 small molecules
  • A comprehensive informatics system for complete data management
  • A focus on the development and validation of robust screening strategies

* All trademarks are the property of their respective owners. Where applicable, the PCR process is covered by patents owned by Roche Molecular Systems, Inc., and F. Hoffman-LaRoche, Ltd.

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