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  Hybritech® free PSA Test

 
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Hybritech® free PSA Test

Measuring your percent free PSA will help improve the accuracy of prostate cancer detection.

PSA exists in multiple forms in the blood. Most is bound to proteins, but some is free-floating. In the early 1990s, it was discovered that measuring the ratio of "free" to "total" PSA could further help in distinguishing prostate cancer from benign prostate disease.

The Hybritech® free PSA test -- also the first test of its kind to receive approval -- helps determine the percent of free PSA. The measurement of percent free PSA improves the accuracy of prostate cancer detection while eliminating a projected 20 percent of all prostate biopsies*. The free PSA test is used following a non-suspicious DRE and a total PSA test that shows moderately elevated PSA levels (between 4 and 10 ng/mL) in men aged 50 years and older.

 
Features
 
  • Original Hybritech free PSA monoclonal antibody pair now on Access!
  • Used with Hybritech PSA to calculate % free PSA
  • Time to first result: 20 minutes
  • Curve stability: 28 days
  • Analytical sensitivity: <0.005 ng/mL
  • Precision: < 7% CV across assay range
  • Measurement range: to 20 ng/mL

 
More Information
 

The table shows that a higher percent free PSA result indicates a lower risk of cancer.

Left: Probability of Prostate Cancer Based on PSA and percent Free PSA results (for men with non-suspicious DRE results, regardless of patient age)

 

 
Characteristics
 

Sample Type/Size

Serum / 25 µL

Time to 1st Result

20 minutes

Analytical Sensitivity

< 0.005 ng/ml

Calibrator Levels

0, 0.5, 2.0, 5.0, 10, and 20 ng/ml

Open Pack Stability

28 days

Calibration Stability

28 days

Precision

< 7% CV

 

 
Ordering Information
 
Name Description Part Type Part Number
Access Hybritech free PSA   2 pack of 50 tests/pack  Reagent  37210 
Access Hybritech free PSA Calibrators  1 vial of 5.0 mL, and 5 vials of 2.5 mL/vial  Calibrator  37215 
Access Hybritech free PSA - QC  2 levels, 1 vial/level of 5 mL/vial  QC (Quality Control)  37219 
 

 

* Catalona WJ, et al. Use of the percentage of free prostate specific antigen to enhance differentiation of prostate cancer from benign prostatic diseases. A prospective multicenter clinical trial. JAMA, 279:1542-1547, 1998.


1. This proposed algorithm is provided as an information tool. It should be interpreted according to individual clinical situations and local medical practice.

2. Hybritech PSA (total) and free PSA should be used to calculate % free PSA.

3. Percent free PSA values should not be interpreted as definitive evidence for the presence or absence of prostate cancer. Prostatic biopsy is required for diagnosis of cancer.


 
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