Genetic Analysis - Applications

Since the first publication of the DNA double helical structure, electrophoresis has been a standard among the analytical tools used for nucleic acid analysis. Capillary electrophoresis (CE) technology extends the power of electrophoresis by using a format that incorporates direct detection, automation and the ability to study interactions in solution.

The following applications are routinely performed on the Beckman Coulter CE-based Genetic analysis systems.

• GeXP and CEQ™ Series Applications (Capillary array technology)
  • Gene Expression
  • Automated Fragment Sizing and Allele Identification
  • Single Nucleotide Polymorphisms (SNP)
  • Short Tandem Repeat (STR) Analysis
  • Amplified Fragment Length Polymorphisms
  • Quantitation / Loss of Heterozygosity
  • Automated Heterozygote Detection
  • Dye Terminator Cycle Sequencing
  • Automated Generation of Locus Tags - Binning
• P/ACE™ MDQ Applications (Single capillary technology)
  • Oligonucleotide Purity
  • Plasmid Analysis
  • Quantitation by Direct Hybridization
  • Single Stranded Conformational Polymorphism (SSCP) Analysis