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The Biomek® FXP ADMETox Workstation, for in-vitro drug permeability measurements, is a validated system that automates the PAMPA (Parallel Artificial Membrane Permeability Analysis) method for the determination of passive absorption of a drug candidate through an artificial lipid membrane. The high-throughput system automates pION's method for PAMPA analysis on Beckman Coulter's Biomek FXP liquid handling system. With PAMPA, the set up and assay run time enable data collection in less than two hours. The PAMPA method mimics the permeability of drug candidates across the intestinal wall in the human gastrointestinal tract. In addition, the PAMPA method can be run on the Biomek FXP ADMETox Workstation to mimic the permeability of drug candidates across the human blood brain barrier. PAMPA Evolution96 software controls all aspects of the permeability assay including all liquid handling steps.
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ADMETox Workstation
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| Part No. |
Description |
| A28762
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Biomek FXP ADMETox Workstation with SpectraMax* Reader
Must be ordered with P/N A24454
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| A29522
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Biomek FXP ADMETox Workstation without SpectraMax Reader
This system does not include an integrated plate reader.
Must be ordered with P/N A24454
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ADMETox Workstation Parts and Accessories
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| Part No. |
Description |
| A24454
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PAMPA Evolution 96 Kit
Kit Includes:
The pION GutBox, PAMPA Evolution 96 Command Software, PAMPA Evolution 96 Desktop Software, PAMPA Starter Kit for 100 tests.
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| A24455
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10-Plate Consumables Kit
Kit Includes:
4 High-Profile Reserviors-5pk (P/N 252110), 2 Low Profile Reserviors-5pk, 4 UV Reading plates-10pk (P/N 024110), 2 PCR* plates-5pk (P/N 186110), 4 GIT(O) lipid-5pk (P/N 669110),
20 Ampoule breakers (P/N 617110), 1 High-Profile 12-trough-5pk (PN 254110), 1 Low-Profile 12-trough (P/N 255110), 2 PAMPA Preloaded Sandwiches-5pk (P/N 212110), 2 Deep-Well Plates-5pk
(P/N 023110), 2 Bottles of System Solutions (P/N 151110), 2 Bottles of ASB pH 7.4 (P/N 139110)
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| A24456
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50-Plate Consumables Kit
Kit Includes:
20 High Profile Reserviors-5pk (P/N 252110), 10 Low Profile Reserviors-5pk, 20 UV Reading plates-10pk (P/N 024110), 10 PCR plates-5pk (P/N 186110), 20 GIT(O) lipid 5pk (P/N 669110),
50 Ampoule breakers (P/N 617110), 5 High-Profile 12-trough-5pk (P/N 254110), 5 Low-Profile 12-trough (P/N 255110), 10 PAMPA Preloaded Sandwiches 5pk (P/N 212110), 10 Deep-Well Plates-5pk (P/N 023110), 10 Bottles of System Solutions (P/N 151110), 10 Bottles of ASB pH 7.4 (P/N 139110)
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