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Instrumentation

Beckman Coulter offers a wide range of innovative cell sorters and analyzers to expand your clinical and research flow cytometry capabilities.

AQUIOS CL

The first true Load & Go Flow Cytometer

Sample preparation and data management usually are the major bottlenecks in routine flow cytometry. Even with a semi-automated process, you and your team may spend hundreds of hours per year for tasks that don‘t add to your laboratory's productivity.

The AQUIOS CL Flow Cytometry System streamlines operations by incorporating automated loading, sample preparation, reagent management, and barcode scanning as well as data analysis and bidirectional LIS connectivity in one compact platform – This is what we call, 'Load & Go Flow Cytometry'.

Features

See what true load-and-go simplicity can bring to your lab

Introducing the new AQUIOS CL with an integrated sample prep module, automated reagent monitoring and barcode scanning, continuous loading with pipeline sample processing, data analysis, bidirectional LIS
connectivity and automated QC.

The fast path to critical test results

What would it mean if your lab could shorten turnaround times and minimize the potential for error in routine lymphocyte subset analysis?  With the AQUIOS CL, you now have the answer—a true load-and-go cytometer for clinical labs.


20+25 = Load-and-go speed and efficiency
  • 20 minutes to the first result following sample load (measured with Tetra-1 or Tetra-2+)
  • 25 results per hour thereafter for up-to one full 96-well plate (measured with Tetra Combo)
 
Easy to learn, easy to operate
  • System users come up-to-speed in one day with computer-based training and an application specialist site visit
  • Eliminate manual pipetting steps with a simplified system design
  • Quickly check sample status for any run with the AQUIOS CL Intelligent Scheduler
 
Fast, efficient and hands-off
  • Fully-integrated sample prep
  • Automated reagent monitoring and barcode scanning capability
  • Automated system setup
  • Continuous loading
  • Automated quality control
  • Full LIS connectivity
  • More compact than traditional modular flow systems

Performance Detail

The ideal solution for routine, high-throughput applications
The AQUIOS CL features full bi-directional Lab Information System (LIS) connectivity to auto-retrieve test requests without manual entry, worklists or middleware.

With pre-loaded standard protocols and operating instructions, the AQUIOS flow cytometer automatically connects sample IDs to test requests and prepares reagents specific to each sample.


Smart-track reagent monitoring
  • Choose from a comprehensive range of bar-coded reagents and consumables
  • Auto-scan and track on-board reagents, open and closed vial expiration dates and remaining tests per vial
  • Easily track remaining and in-use test wells with scanned microplate functionality

Real-time monitoring and quality control
  • The system continually tracks reagent status to ensure availability and proper use
  • Multiple audit functions ensure process compliance


Continuous loading
Continuous loading/unloading capability is available with multiple cassettes on a single autoloader for a total capacity of 40 sample tubes.  With continuous loading, the AQUIOS CL can complete an entire 96 sample well-plate without stopping.  A single-tube loader processes STAT samples in the next available slot including irregular tube sizes and open-vial sampling.


Sample Prep – random sample loading
The barcode on each sample tube identifies which test to run and the scanners match the specimen ID, test request and all necessary reagents.

Eliminate manual pipetting and potential biohazard issues with no daughter tubes to label and track and no transporting of prepared samples.

  • Cap pierces blood tubes
  • Aspirates correct sample volumes
  • Assigns samples to internal well plate
  • Adds and mixes reagents in correct volumes and sequence

Pipeline sample processing
This patent-pending feature eliminates slow, inefficient batch processing to enhance overall efficacy and processing times. Two multitasking probes—one dedicated to cap piercing and sample prep and the other to aspirating samples for analysis—ensures standardized sample preparation and fast efficient analysis.


Intelligent analysis algorithm
In the Tetra combo for lymphocyte subset analysis, first sample results are reported within 20 minutes of loading.  Subsequent sample results are reported ~every two minutes.  The algorithm auto-sets gates, regions and compensation to flag samples that don’t meet auto-validation criteria or require operator review. Real-time on-screen detail includes a results summary complete with histograms, dot plots, adjustable gates and region, and compensation


Advanced failure prevention and quality control
  • To ensure the integrity of test results, antibody vials remain sealed preventing dye degradation due to light or air
  • Vials have pierceable caps eliminating the need to remove track multiple cap locations
  • Laser output is continuously monitored and adjusted
  • Volumetric absolute counting eliminates count tubes and beads removing manual pipetting risks
  • Simultaneous quality control checks for every sample and process control run
  • System-based audit trail eliminates need for manual quality control or reagent log books required (includes tracking assay values for process controls)
  • Text and/or email auto-alert triggers for reagent replenishment or when operator intervention is required
  • Auto-transmit test results with LIS connectivity without manual data entry or middleware*

*Results should be reviewed by a qualified person prior to release of results from the LIS.

AQUIOS Reagents

High Performance
AQUIOS reagents have been optimized for peak performance when used with the AQUIOS CL Flow Cytometer. An integral part of the system, they deliver a high level of reliability to the user. With AQUIOS reagents, there is no need to mix your own monoclonal antibodies.

The stated analytical characteristics and specifications for the AQUIOS system can only be guaranteed by using AQUIOS reagents and the AQUIOS Deep Well Plate.

Convenient  

All AQUIOS reagents, with the exception of Sodium Hypochlorite, are barcoded for fast loading and minimal errors.  Auto-detection functionality automatically log onboard reagent detail such as lot number, expiration date and product ID. AQUIOS Sheath Solution and Cleaning Agent are captured by the user via the system barcode eliminating any need for manual entry.

Smart-track reagent monitoring 

Reagent use is automatically tracked by the system providing users with key usage data including remaining reagent volume and user-selected alerts for specific condition sets.  AQUIOS reagents (with the exception of Sodium Hypochlorite Solution) and the deep well plates are also labeled to help minimize the potential for error. The system will only run with AQUIOS reagents and the AQUIOS deep well plates.

Cost-effective 

AQUIOS reagents are designed to the highest quality standards to deliver the best for less. Compare the significant difference between how many reagents are required in traditional flow cytometry versus the number of reagents required for AQUIOS-based workflows.

AQUIOS Tetra-1 Panel–No experimenting, mixing, validating required  

AQUIOS Tetra-1 Panel Monoclonal Antibody* reagents is a four-color monoclonal antibody cocktail consisting of CD45-FITC/CD4-RD1/CD8-ECD/CD3-PC5 used in the identification and enumeration of total CD3+, CD3+CD4+, CD3+CD8+, CD3+CD4+/CD3+CD8+ (ratio only) lymphocyte percentages and absolute counts in peripheral whole blood.

  • Formula optimized for the highest performance on the AQUIOS flow cytometer
  • AQUIOS monoclonal reagent vials are cap pierceable
  • Barcoded vials to allow loading in random order
  • High-volume labs can load multiple vials (50 tests/vial) in reagent carousel and system will auto-detect reagent vials for continuous use, as needed
* Part Number B23533, 50 tests

AQUIOS Tetra-2+ Panel–No experimenting, mixing, validating required  

AQUIOS Tetra-2+ Panel Monoclonal Antibody* reagents is a four-color monoclonal antibody cocktail consisting of CD45-FITC/(CD56 + CD16)-RD1/CD19-ECD/CD3-PC5 for identification and enumeration of total CD3+, CD3-CD19+, CD3-CD56+ and/or CD16+ lymphocyte percentages and absolute counts in peripheral whole blood.

  • Formula optimized for the highest performance on the AQUIOS flow cytometer system
  • AQUIOS monoclonal reagent vials are cap pierceable
  • Barcoded vials to allow loading in random order
  • High-volume labs can load multiple vials (50 tests/vial) in reagent carousel and system will auto-detect reagent vials for continuous use, as needed

*Part Number B23534, 50 tests

AQUIOS Lysing Reagent Kit  

The AQUIOS Lysing reagent kit* is used as part of the AQUIOS flow cytometer system. The kit consists of two reagents used by AQUIOS flow cytometers to prepare whole blood samples for analysis of white blood cells.

  • Reagent A for lysing red blood cells in whole blood samples sufficient to perform monoclonal antibody panel analysis without interference from red blood cells
  • B. Reagent slows the lysing reaction sufficiently to allow analysis without damage to white blood cells
  • Lysing reagents are placed onboard the system and are barcoded to detect and track presence and position
  • High-volume users can load multiple containers and the system will automatically deploy, as needed

*Part Number B23538, 100 tests

AQUIOS IMMUNO-TROL Cells  

AQUIOS IMMUNO-TROL Cells is an assayed, lysable whole blood quality-control product* for immunophenotyping analysis using monoclonal antibody reagents and flow cytometry for positive cell control processed similarly to whole blood samples.

  • For verification of instrument and reagent performance as well as methods used for staining targeted cells, lysing of erythrocytes, and analysis of samples by the AQUIOS CL flow cytometer
  • Tetra-1 Panel or Tetra-2+ Panel tests include 15 tests per tube
  • Tetra Combo includes 10 tests per tube
  • Each cap should have no more than 15 total piercings

*Part Number B23535, 2 x 3mL

AQUIOS IMMUNO-TROL Low Cells  

AQUIOS IMMUNO-TROL Low Cells is an assayed, lysable whole blood quality control product* for immunophenotyping analysis using monoclonal antibody reagents and flow cytometry for positive cell control processed similarly to whole blood samples.

  • For verification of instrument and reagent performance as well as methods used for staining targeted cells, lysing of erythrocytes and sample analysis using the AQUIOS CL flow cytometer
  • Tetra-1 Panel or Tetra-2+ Panel tests include 15 tests per tube
  • Tetra Combo includes 10 tests per tube
  • Each cap should have no more than 15 total piercings

*Part Number B25700, 2 x 3mL


AQUIOS Sheath Solution

AQUIOS Sheath Solution* is a non-fluorescent, azide-free balanced electrolyte solution for use on AQUIOS flow cytometers with light scatter and fluorescent applications.

*Part Number B25697, 10L

AQUIOS Cleaning Agent

A cleaning agent* for use on AQUIOS flow cytometer components that come in contact with blood samples.

  • Azide-free, formaldehyde-free, biodegradable cleaner containing a proteolytic enzyme that aids in the removal of protein buildup in the fluidics system and flow cell of a flow cytometer
  • Cleaning agent resides onboard for use in automatic cleaning cycles

*Part Number B25698, 500mL

AQUIOS Sodium Hypochlorite Solution

AQUIOS Sodium Hypochlorite solution* can be used as a preventative and corrective cleaning agent to maintain AQUIOS instruments in optimal condition.

*Part Number B23536, 4 x 50mL

AQUIOS Consumables

Consumables for the AQUIOS CL System     
AQUIOS consumables have been optimized for peak performance when used with the AQUIOS CL Flow Cytometer. The Aquios CL is equipped with an automatic sample loader that utilizes cassettes to queue samples for preparation and analysis.

Each cassette holds up to five specimen tubes. Up to eight cassettes, a maximum of 40 specimens, can be loaded at one time. Cassettes can be loaded and unloaded without interrupting the system’s workflow.


AQUIOS Deep Well Plate 

96-well, conical bottom microplate that optimizes the sample prep in the AQUIOS system.

  • High-quality deep-well design made of virgin polypropylene
  • Unique barcode automatically read when placed onboard the system for tracking sample locations
Part number B23502, 50 plates/case  


Waste Collection Container     

Empty 10L cubes present a convenient waste collection container to ensure no interruption in runs.

Part number 7547155, 10L size  


Cassettes 
  • AQUIOS automatic sample loader uses cassettes to queue samples for preparation and analysis
  • Specimen cassettes are compatible with a variety of blood collection tubes
 
Product Number Cassette Type
B25218 Cassette Type 1, 12-13mm X 75mm
B25219 Cassette Type 2, 12-13mm X 100mm
B25220 Cassette Type 3, 16mm X 100mm
B25221 Cassette Type 4, 10.25mm X 50mm
B25318 Cassette Type 5, Control
B25918 Cassette Type 6, Sarstedt

AQUIOS Designer Software

Your assays. Standardized and prepared automatically

Many laboratories create their own reagent cocktails for routine applications in order to accommodate the marker combinations they need. With the optional AQUIOS Designer Software, it is now possible to set up your own user-defined assays on the AQUIOS CL flow cytometer.

Create user-defined protocols and panels

The intuitive interface of AQUIOS Designer Software allows you to create the protocols, acquisition templates, panels, compensation settings, and statistic/QC parameters that you need for your specific assay.

Adapt sample preparation to your needs

AQUIOS CL combines sample preparation and analysis in one compact platform. With AQUIOS Designer Software, each step in the sample preparation process (volumes, incubation times, mix cycles) can be adapted to your specific requirements. To customize your assay even more, AQUIOS Designer Software supports the use of different lysing options and can derive absolute cell counts using either reference beads or the AQUIOS volumetric absolute counting methodology.

Barcoded reagents

In order to take advantage of the automation features of the AQUIOS CL system, Beckman Coulter provides the reagents for your user-defined assays either through our Contract Manufacturing (GMP) or Custom Design* Services of user defined reagents. Either option provides barcoded and cap-pierceable vials that can be run on the AQUIOS CL instrument.

Under Beckman Coulter‘s Contract Manufacturing Services, we manufacture the components of your user defined test reagents under GMP conditions according to your specifications.

Our Custom Design Services* go even one step further, in that our antibody experts assist you in panel design and reagent formulation.

* Custom Design Services products are For Research Use Only. Not for use in diagnostic procedures.

Training Courses

File/Info Title Ref. Number
AQUIOS CL Advanced Operator Online Training
AQUIOS CL Basic Operator Online Training
AQUIOS CL Tetra Application Training

Videos

  • How the AQUIOS Works - Analysis and Reporting

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  • How the AQUIOS Works - Auto / Single Loader

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  • How the AQUIOS Works - Automation

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  • How the AQUIOS Works - Introduction

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  • How the AQUIOS Works - Pipeline Sample Processing

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  • How the AQUIOS Works - Quality Control

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  • How the AQUIOS Works - Sample Prep

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  • How the AQUIOS Works - Smart Track Reagent Monitoring

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  • How the AQUIOS Works - Workflow Efficiency

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  • Testimonial: Alexandra Amador (Part 1)

    Click to play  

  • Testimonial: Alexandra Amador (Part 2)

    Click to play  

  • Testimonial: Casiana Fernandez-Bango (Part 1)

    Click to play  

  • Testimonial: Casiana Fernandez-Bango (Part 2)

    Click to play  

  • The AQUIOS Advantage

    Click to play  

  • Products

    Flow Cytometry Instruments & Software - Clinical Diagnostics

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    B39101

    AQUIOS CL System W/UPS (110-120V)

    488 nm Solid State Diode Laser

    IVD & CE

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    B39102

    AQUIOS CL System W/UPS (220-240V)

    488 nm Solid State Diode Laser

    IVD & CE

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    B25698

    AQUIOS Cleaning Agent, 500 mL

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    $44.00

    B23538

    AQUIOS Lysing Reagent Kit, 100 tests

    IVD & CE

    $510.00

    B25697

    AQUIOS Sheath Solution, 10 L

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    $26.00

    B23536

    Aquios Sodium Hypochlorite Solution, 4 x 50 mL

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    $200.00

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