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Applications

Transform the efficiency and reliability of your research with Beckman Coulter automated lab protocols. Discover protocol information and insights relevant to your application here.

Next Generation Sequencing

Accelerated NGS Workflow Efficiency Within Your Reach

Next generation sequencing sample preparation can involve many tedious and error prone steps. Beckman Coulter Life Sciences provides solutions to help standardize your processes and achieve more consistent results. Our automation and genomics product offerings span the majority of your NGS workflow including the major steps of DNA & RNA extraction, library construction, quality checks and pooling. We currently offer a large number of demonstrated, Biomek-automated methods using popular reagent kits to support evolving research needs.

Let us help you accelerate reliable results so you can move to the next step with certainty.

 

Automated Methods Card

We currently offer a large number of demonstrated, Biomek-automated methods using popular reagent kits to support evolving research needs.

Automated NGS Method Card

Click to download our current listing of Biomek-Automated NGS Library Construction & Nucleic Acid Sample Prep Methods.

Liquid Handling & RoboticsBiomek-Automated NGS Library Construction Methods
 
DEMONSTRATED METHOD
BIOMEK FXP
HYBRID
BIOMEK FXP
MULTI-CHANNEL
BIOMEK FXP
SPAN 8
BIOMEK NXP
SPAN 8
BIOMEK NXP
MULTI-CHANNEL
BIOMEK 4000
CANCER PANELS Illumina TruSight® Cancer          
Illumina TruSight® Tumor 15          
DNA
SEQUENCING
Illumina Nextera® XT          
Illumina TruSeq® DNA PCR-Free        
Illumina TruSeq® Nano DNA      
Illumina TruSeq® Custom Amplicon Low Input Kit          
KAPA Hyper Prep Library Prep Kit for Illumina NGS          
KAPA HyperPlus Library Prep Kit for Illumina NGS          
NEBNext® Ultra DNA for Illumina NGS (ChIP-seq and HLA)          
NEBNext® Ultra DNA II Kit for Illumina NGS          
Rubicon Genomics ThruPLEX® Plasma-seq Kit for Illumina NGS          
Swift Biosciences Accel - NGS® 2S Plus DNA Library Kit for Illumina NGS          
HLA TYPING Illumina TruSight® HLA Sequencing Panel v2          
Immucor Mia Fora NGS      
Omixon Holotype HLA X2          
RNA
SEQUENCING
Illumina TruSeq® RNA v2          
Illumina TruSeq® RNA Access          
Illumina TruSeq® Stranded mRNA          
Illumina TruSeq® Stranded Total RNA          
NEBNext® Small RNA Kit for Illumina NGS          
NEBNext® Ultra Directional RNA Library Kit for Illumina NGS          
TARGET/EXOME
CAPTURE
Agilent HaloPlex™ Target Enrichment - Ion Torrent      
Agilent SureSelect XT®          
Epicentre ScriptSeq® Complete Gold Low Input          
Illumina Nextera® Rapid Capture          
Illumina TruSeq® Exome          
Illumina TruSeq® Rapid Exome          
Nimblegen SeqCap EZ® for Illumina NGS          
 
Liquid Handling & RoboticsBiomek-Automated Nucleic Acid Sample Preparation Methods
 
DEMONSTRATED METHOD
BIOMEK FXP
HYBRID
BIOMEK FXP
MULTI-CHANNEL
BIOMEK FXP
SPAN 8
BIOMEK NXP
SPAN 8
BIOMEK NXP
MULTI-CHANNEL
BIOMEK 4000
DNA AND RNA
PURIFICATION
AND CLEAN UP/
SIZE SELECTION/
QUANTITATION/
NORMALIZATION/
POOLING
AMPure XP - PCR Purification  
CleanSEQ - Dye Terminator Removal    
KAPA Biosystems Library Quantification Kit - Illumina        
qPCR setup 384      
qPCR setup 96      
Quantitation/Normalization      
RNAClean XP - Post cDNA Purification and Post-IVT cRNA Purification    
SPRIselect for DNA Size Selection      
Sample Pooling for Multiplexing          
NUCLEIC ACID
ISOLATION
CosMCPrep - High/Low Copy Plasmid Extraction      
DNAdvance - DNA Isolation from Mammalian Tissue    
FormaPure DNA - DNA Isolation from FFPE Tissue          
FormaPure - RNA Isolation from FFPE Tissue      
Mo Bio PowerMag Soil DNA Isolation Kit          
RNAdvance Tissue      
RNAdvance Cell v2 - RNA Isolation from Tissues  
 

Method Key

Demonstrated Method developed for a sample preparation kit following a vendor’s published manual protocol. Each one is tested with relevant samples and has yielded results that meet the kit vendor’s specifications either in a customer lab (customer demonstrated) or in a Beckman Coulter Life Sciences Lab (Beckman demonstrated). Beckman Coulter makes no claims regarding the use or performance of these methods.
Methods currently in the data generation phase of development.
Illumina Qualified Method, which indicates that Illumina’s analysis of libraries prepared with the Biomek-automated method has shown the libraries to perform comparably to those prepared manually. This method is not an Illumina product, and Illumina does not support this product. Illumina makes no representations or warranties with respect to this product.
Method created and provided by kit vendor.
 

Methods are intended for molecular biology research applications. They are not intended, verified or validated, for use in the diagnosis of disease or other conditions.
* All trademarks used throughout this document are the property of their respective owners.

Webinars & Symposiums

  • Advancing Translational Cancer Research through Automated RNASeq Sample Preparation from Archival FFPE Tissue Specimens

    Michela Bowden, PhD, Dana Farber Cancer Institute

    Click to play  

  • Automated NEBNext Ultra Directional RNA Library Prep Kit for Illumina Effective Strand Specific RNA Library Preparation from Low Input Samples

    Click to play  

  • Automated TruSeq RNA Sample Prep

    Michela Bowden, PhD, Dana Farber Cancer Institute

    Click to play  

  • Automating High-Throughput Sample Prep for Analysis of Complex Diseases Using Next-Gen Sequencing

    Shawn Levy, PhD, HudsonAlpha Institute for Biotechnology

    Click to play  

  • Automation of PCR Setup and AMPure XP Purification using the Biomek 4000 Workstation

    Dr. Li Liu Sr. Development Scientist Beckman Coulter Life Sciences

    Click to play  

  • Biomek Automated NEBNext Ultra Directional RNA Library Prep Kit for Illumina Effective Strand Specific RNA Library Preparation from Low Input Samples

    Fiona Stewart, Next Generation Sequencing Product Marketing Manager New England Biolabs, Inc. Zach Smith, Senior Applications Scientist Beckman Coulter, Inc.

    Click to play  

  • Challenging Samples in Cancer Research: Formalin-Fixed Paraffin-Embedded Tissues

    Kathy Munkvold, PhD Staff Development Scientist Beckman Coulter Life Sciences

    Click to play  

    Increasingly, Formalin-Fixed, Paraffin-Embedded (FFPE) samples are an essential part of many next-generation sequencing (NGS) sample prep workflows, specifically in the field of cancer research. High quality extraction protocols focused on...

  • Improve Yield and Quality from RNA and miRNA Extractions from FFPE Tissue

    Alexandra Scavo PhD, Sr. Applications Scientist, Beckman Coulter, Inc. and Bee Na Lee PhD, Sr. Applications Scientist, Beckman Coulter, Inc.

    Click to play  

  • Increase Productivity & Reproducibility by Automating DNA Library Prep for Ion Torrent Sequencing

    Joanna Hamilton, PhD, Co-Director, Dartmouth Genomics & Molecular Biology Shared Resource Lynne Apone, Applications and Product Development Scientist, New England Biolabs Zach Smith, Senior Applicat

    Click to play  

  • Intro to NGS Automation (1 of 3): Simple Automation Solutions. Better Results.

    Click to play  

    Generating NGS data you can trust is highly reliant on the quality of the library sample that’s sequenced.  NGS sample prep has become more streamlined, but it’s still a labor intensive process highly prone to error. Liquid...
  • Intro to NGS Automation (2 of 3) DNA & RNA Sequencing Sample Prep: Automating Simple to Complex Methods

    Click to play  

    DNA and RNA sequencing sample preparation can involve many tedious and error prone steps. Liquid handling automation solutions can help standardize your processes and achieve more consistent results. Beckman Coulter Life Sciences automation and...

  • Intro to NGS Automation (3 of 3) Mission Possible: Automating NGS sample prep for challenging samples and niche applications

    Click to play  

    Accelerating discoveries to improve human and environmental health often require the implementation of niche applications that may involve complex processes and working with challenging samples. 

    During the final...

  • miRNA Enrichment and RNA Size Selection using SPRI (Solid Phase Revesible Immobilization) Paramagnetic Bead Technology

    Bee Na Lee, PhD, Staff Application Scientist, Beckman Coulter

    Click to play  

  • PCR-Setup and AMPure XP DNA Purification on Biomek 4000 Workstation (displayed with optional enclosure)

    Li Liu, Ph.D. Sr. Development Scientist Beckman Coulter Life Sciences

    Click to play  

    PCR reaction setup is time-consuming and error-prone by manual pipetting. Post-PCR cleanup is tedious and labor intensive but very important for downstream applications, such as sequencing, ligation and cloning.

    This Webinar will...

  • Preparing Your Clinical Laboratory for High Throughput Buccal Swab DNA Purification

    Click to play  

  • Taking the “Tricky” Out of Automating NGS Sample Prep

    Mary Blair, Senior Applications Scientist, Beckman Coulter

    Click to play  

  • TruSeq RNA Automated on Biomek FXᴾ

    Click to play  

  • Unlocking FFPE tissues using Illumina NGS Biomek Automated Sample Preparation

    Michaela Bowden PhD, CMOP Associate Director, Dana Farber Cancer Institute Mary Blair, Senior Application Scientist, Beckman Coulter, Inc.

    Click to play  

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